YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

• Main Authors: Li, Z.-Y, Chung, Y.H, Shin, E.-J, Dang, D.-K, Jeong, J.H, Ko, S.K, Nah, S.-Y, Baik, T.G, Jhoo, J.H, Ong, W.-Y, Nabeshima, T, Kim, H.-C
• Other Authors: ANATOMY
• Format: Article
• Published: 2020
• Subjects: 1 alkyl 2 acetylglycerophosphocholine esterase; 1 alkyl 2 acetylglycerophosphocholine esterase 1; amyloid beta protein[1-42]; amyloid precursor protein; bilobalide; cyclooxygenase 2; Ginkgo biloba extract; ginkgolide A; ginkgolide B; ginkgolide C; isorhamnetin; kaempferol; meloxicam; presenilin 1; quercetin; reactive oxygen metabolite; terpene; thrombocyte activating factor receptor; unclassified drug; yy 1224; amyloid beta protein; amyloid beta-protein (1-42); lactone; peptide fragment; plant extract; trilactone; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; Article; controlled study; COX 2 gene; down regulation; enzyme inhibition; gene expression regulation; knockout mouse; learning disorder; memory disorder; microglia; mouse; nerve cell stimulation; neuroprotection; neurotropism; nonhuman; PAF acetylhydrolase 1 gene; pilot study; platelet activating factor receptor gene; protein expression; protein localization; retreatment; transgenic mouse; upregulation; Alzheimer disease; animal; antagonists and inhibitors; biosynthesis; degenerative disease; gene expression; genetics; Ginkgo biloba; isolation and purification; metabolism; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cyclooxygenase 2; Gene Expression; Lactones; Mice; Mice, Knockout; Mice, Transgenic; Neurodegenerative Diseases; Peptide Fragments; Plant Extracts; Presenilin-1; Reactive Oxygen Species; Terpenes
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179510
• Institution: National University of Singapore

10.1186/s12974-017-0866-x