Blocking the PI3K/AKT pathway enhances mammalian reovirus replication by repressing IFN-stimulated genes

• Main Authors: Tian, J, Zhang, X, Wu, H, Liu, C, Li, Z, Hu, X, Su, S, Wang, L.-F, Qu, L
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: chlorpromazine; clathrin; focal adhesion kinase; Gab1 protein; genistein; interferon; membrane protein; phosphatidylinositol 3 kinase; protein kinase B; protein p85; small interfering RNA; unclassified drug; wortmannin; Article; caveola; controlled study; down regulation; endocytosis; enzyme linked immunosorbent assay; gene; gene expression; human; human cell; in vitro study; interferon gene; intracellular signaling; luciferase assay; molecular cloning; nonhuman; phylogeny; protein phosphorylation; real time polymerase chain reaction; Reoviridae; reovirus infection; reverse transcription polymerase chain reaction; RNA synthesis; serotype; upregulation; virion; virus inactivation; virus replication; Western blotting
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180930
• Institution: National University of Singapore

10.3389/fmicb.2015.00886