Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer

10.18632/oncotarget.2188

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Main Authors:	Li, C, Wang, J, Hu, J, Feng, Y, Hasegawa, K, Peng, X, Duan, X, Zhao, A, Mikitsh, J.L, Muzykantov, V.R, Chacko, A.-M, Pryma, D.A, Dunn, S.M, Coukos, G
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2020
Subjects:	endosialin hybrid protein single chain fragment variable antibody tracer tumor marker CD248 protein, human immunoglobulin fragment leukocyte antigen tumor antigen animal cell animal experiment animal model Article binding affinity breast cancer cancer graft controlled study enzyme linked immunosorbent assay fluorescence imaging immunoreactivity in vitro study in vivo study isotope labeling lymph node metastasis mouse near infrared imaging system neoplasm nonhuman ovary cancer patient selection positron emission tomography process optimization protein purification protein stability radioactivity single photon emission computer tomography thermostability tomography tumor vascularization validation process Western blotting animal chemistry disease model genetic transfection genetics human immunology nude mouse tissue distribution tumor cell line xenograft Animals Antigens, CD Antigens, Neoplasm Cell Line, Tumor Disease Models, Animal Heterografts Humans Immunoglobulin Fragments Mice Mice, Nude Neoplasms Optical Imaging Recombinant Fusion Proteins Tissue Distribution Transfection
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181778
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1817782023-09-07T22:06:46Z Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer Li, C Wang, J Hu, J Feng, Y Hasegawa, K Peng, X Duan, X Zhao, A Mikitsh, J.L Muzykantov, V.R Chacko, A.-M Pryma, D.A Dunn, S.M Coukos, G DUKE-NUS MEDICAL SCHOOL endosialin hybrid protein single chain fragment variable antibody tracer tumor marker CD248 protein, human hybrid protein immunoglobulin fragment leukocyte antigen tumor antigen animal cell animal experiment animal model Article binding affinity breast cancer cancer graft controlled study enzyme linked immunosorbent assay fluorescence imaging immunoreactivity in vitro study in vivo study isotope labeling lymph node metastasis mouse near infrared imaging system neoplasm nonhuman ovary cancer patient selection positron emission tomography process optimization protein purification protein stability radioactivity single photon emission computer tomography thermostability tomography tumor vascularization validation process Western blotting animal chemistry disease model fluorescence imaging genetic transfection genetics human immunology neoplasm nude mouse tissue distribution tumor cell line xenograft Animals Antigens, CD Antigens, Neoplasm Cell Line, Tumor Disease Models, Animal Heterografts Humans Immunoglobulin Fragments Mice Mice, Nude Neoplasms Optical Imaging Recombinant Fusion Proteins Tissue Distribution Transfection 10.18632/oncotarget.2188 Oncotarget 5 16 6994-7012 2020-10-28T07:11:35Z 2020-10-28T07:11:35Z 2014 Article Li, C, Wang, J, Hu, J, Feng, Y, Hasegawa, K, Peng, X, Duan, X, Zhao, A, Mikitsh, J.L, Muzykantov, V.R, Chacko, A.-M, Pryma, D.A, Dunn, S.M, Coukos, G (2014). Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer. Oncotarget 5 (16) : 6994-7012. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.2188 19492553 https://scholarbank.nus.edu.sg/handle/10635/181778 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	endosialin hybrid protein single chain fragment variable antibody tracer tumor marker CD248 protein, human hybrid protein immunoglobulin fragment leukocyte antigen tumor antigen animal cell animal experiment animal model Article binding affinity breast cancer cancer graft controlled study enzyme linked immunosorbent assay fluorescence imaging immunoreactivity in vitro study in vivo study isotope labeling lymph node metastasis mouse near infrared imaging system neoplasm nonhuman ovary cancer patient selection positron emission tomography process optimization protein purification protein stability radioactivity single photon emission computer tomography thermostability tomography tumor vascularization validation process Western blotting animal chemistry disease model fluorescence imaging genetic transfection genetics human immunology neoplasm nude mouse tissue distribution tumor cell line xenograft Animals Antigens, CD Antigens, Neoplasm Cell Line, Tumor Disease Models, Animal Heterografts Humans Immunoglobulin Fragments Mice Mice, Nude Neoplasms Optical Imaging Recombinant Fusion Proteins Tissue Distribution Transfection
spellingShingle	endosialin hybrid protein single chain fragment variable antibody tracer tumor marker CD248 protein, human hybrid protein immunoglobulin fragment leukocyte antigen tumor antigen animal cell animal experiment animal model Article binding affinity breast cancer cancer graft controlled study enzyme linked immunosorbent assay fluorescence imaging immunoreactivity in vitro study in vivo study isotope labeling lymph node metastasis mouse near infrared imaging system neoplasm nonhuman ovary cancer patient selection positron emission tomography process optimization protein purification protein stability radioactivity single photon emission computer tomography thermostability tomography tumor vascularization validation process Western blotting animal chemistry disease model fluorescence imaging genetic transfection genetics human immunology neoplasm nude mouse tissue distribution tumor cell line xenograft Animals Antigens, CD Antigens, Neoplasm Cell Line, Tumor Disease Models, Animal Heterografts Humans Immunoglobulin Fragments Mice Mice, Nude Neoplasms Optical Imaging Recombinant Fusion Proteins Tissue Distribution Transfection Li, C Wang, J Hu, J Feng, Y Hasegawa, K Peng, X Duan, X Zhao, A Mikitsh, J.L Muzykantov, V.R Chacko, A.-M Pryma, D.A Dunn, S.M Coukos, G Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer
description	10.18632/oncotarget.2188
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Li, C Wang, J Hu, J Feng, Y Hasegawa, K Peng, X Duan, X Zhao, A Mikitsh, J.L Muzykantov, V.R Chacko, A.-M Pryma, D.A Dunn, S.M Coukos, G
format	Article
author	Li, C Wang, J Hu, J Feng, Y Hasegawa, K Peng, X Duan, X Zhao, A Mikitsh, J.L Muzykantov, V.R Chacko, A.-M Pryma, D.A Dunn, S.M Coukos, G
author_sort	Li, C
title	Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer
title_short	Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer
title_full	Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer
title_fullStr	Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer
title_full_unstemmed	Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer
title_sort	development, optimization, and validation of novel anti-tem1/cd248 affinity agent for optical imaging in cancer
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/181778
_version_	1779152877209518080

Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer

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