Early oral stepdown antibiotic therapy versus continuing intravenous therapy for uncomplicated Gram-negative bacteraemia (the INVEST trial): study protocol for a multicentre, randomised controlled, open-label, phase III, non-inferiority trial
10.1186/s13063-022-06495-3
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2022
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sg-nus-scholar.10635-2303972024-04-18T02:16:42Z Early oral stepdown antibiotic therapy versus continuing intravenous therapy for uncomplicated Gram-negative bacteraemia (the INVEST trial): study protocol for a multicentre, randomised controlled, open-label, phase III, non-inferiority trial Lee, I Russel Tong, Steven YC Davis, Joshua S Paterson, David L Syed-Omar, Sharifah F Peck, Kwong Ran Chung, Doo Ryeon Cooke, Graham S Libau, Eshele Anak Rahman, Siti-Nabilah BA Gandhi, Mihir P Shi, Luming Zheng, Shuwei Chaung, Jenna Tan, Seow Yen Kalimuddin, Shirin Archuleta, Sophia Lye, David C BIOCHEMISTRY MEDICINE DEAN'S OFFICE (SSH SCH OF PUBLIC HEALTH) DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) DUKE-NUS MEDICAL SCHOOL Science & Technology Life Sciences & Biomedicine Medicine, Research & Experimental Research & Experimental Medicine Gram-negative bacteraemia Antibiotics Early oral stepdown therapy Oral fluoroquinolones Oral trimethoprim-sulfamethoxazole Health economic evaluation Quality of life CIPROFLOXACIN INFECTION 10.1186/s13063-022-06495-3 TRIALS 23 1 2022-08-18T08:22:59Z 2022-08-18T08:22:59Z 2022-07-19 2022-08-18T08:20:44Z Article Lee, I Russel, Tong, Steven YC, Davis, Joshua S, Paterson, David L, Syed-Omar, Sharifah F, Peck, Kwong Ran, Chung, Doo Ryeon, Cooke, Graham S, Libau, Eshele Anak, Rahman, Siti-Nabilah BA, Gandhi, Mihir P, Shi, Luming, Zheng, Shuwei, Chaung, Jenna, Tan, Seow Yen, Kalimuddin, Shirin, Archuleta, Sophia, Lye, David C (2022-07-19). Early oral stepdown antibiotic therapy versus continuing intravenous therapy for uncomplicated Gram-negative bacteraemia (the INVEST trial): study protocol for a multicentre, randomised controlled, open-label, phase III, non-inferiority trial. TRIALS 23 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s13063-022-06495-3 1745-6215 1745-6215 https://scholarbank.nus.edu.sg/handle/10635/230397 en BMC Elements |
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Singapore Singapore |
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English |
| topic |
Science & Technology Life Sciences & Biomedicine Medicine, Research & Experimental Research & Experimental Medicine Gram-negative bacteraemia Antibiotics Early oral stepdown therapy Oral fluoroquinolones Oral trimethoprim-sulfamethoxazole Health economic evaluation Quality of life CIPROFLOXACIN INFECTION |
| spellingShingle |
Science & Technology Life Sciences & Biomedicine Medicine, Research & Experimental Research & Experimental Medicine Gram-negative bacteraemia Antibiotics Early oral stepdown therapy Oral fluoroquinolones Oral trimethoprim-sulfamethoxazole Health economic evaluation Quality of life CIPROFLOXACIN INFECTION Lee, I Russel Tong, Steven YC Davis, Joshua S Paterson, David L Syed-Omar, Sharifah F Peck, Kwong Ran Chung, Doo Ryeon Cooke, Graham S Libau, Eshele Anak Rahman, Siti-Nabilah BA Gandhi, Mihir P Shi, Luming Zheng, Shuwei Chaung, Jenna Tan, Seow Yen Kalimuddin, Shirin Archuleta, Sophia Lye, David C Early oral stepdown antibiotic therapy versus continuing intravenous therapy for uncomplicated Gram-negative bacteraemia (the INVEST trial): study protocol for a multicentre, randomised controlled, open-label, phase III, non-inferiority trial |
| description |
10.1186/s13063-022-06495-3 |
| author2 |
BIOCHEMISTRY |
| author_facet |
BIOCHEMISTRY Lee, I Russel Tong, Steven YC Davis, Joshua S Paterson, David L Syed-Omar, Sharifah F Peck, Kwong Ran Chung, Doo Ryeon Cooke, Graham S Libau, Eshele Anak Rahman, Siti-Nabilah BA Gandhi, Mihir P Shi, Luming Zheng, Shuwei Chaung, Jenna Tan, Seow Yen Kalimuddin, Shirin Archuleta, Sophia Lye, David C |
| format |
Article |
| author |
Lee, I Russel Tong, Steven YC Davis, Joshua S Paterson, David L Syed-Omar, Sharifah F Peck, Kwong Ran Chung, Doo Ryeon Cooke, Graham S Libau, Eshele Anak Rahman, Siti-Nabilah BA Gandhi, Mihir P Shi, Luming Zheng, Shuwei Chaung, Jenna Tan, Seow Yen Kalimuddin, Shirin Archuleta, Sophia Lye, David C |
| author_sort |
Lee, I Russel |
| title |
Early oral stepdown antibiotic therapy versus continuing intravenous therapy for uncomplicated Gram-negative bacteraemia (the INVEST trial): study protocol for a multicentre, randomised controlled, open-label, phase III, non-inferiority trial |
| title_short |
Early oral stepdown antibiotic therapy versus continuing intravenous therapy for uncomplicated Gram-negative bacteraemia (the INVEST trial): study protocol for a multicentre, randomised controlled, open-label, phase III, non-inferiority trial |
| title_full |
Early oral stepdown antibiotic therapy versus continuing intravenous therapy for uncomplicated Gram-negative bacteraemia (the INVEST trial): study protocol for a multicentre, randomised controlled, open-label, phase III, non-inferiority trial |
| title_fullStr |
Early oral stepdown antibiotic therapy versus continuing intravenous therapy for uncomplicated Gram-negative bacteraemia (the INVEST trial): study protocol for a multicentre, randomised controlled, open-label, phase III, non-inferiority trial |
| title_full_unstemmed |
Early oral stepdown antibiotic therapy versus continuing intravenous therapy for uncomplicated Gram-negative bacteraemia (the INVEST trial): study protocol for a multicentre, randomised controlled, open-label, phase III, non-inferiority trial |
| title_sort |
early oral stepdown antibiotic therapy versus continuing intravenous therapy for uncomplicated gram-negative bacteraemia (the invest trial): study protocol for a multicentre, randomised controlled, open-label, phase iii, non-inferiority trial |
| publisher |
BMC |
| publishDate |
2022 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/230397 |
| _version_ |
1800915557815418880 |