Polygenic hazard scores in preclinical Alzheimer's disease

Identifying asymptomatic older individuals at elevated risk for developing Alzheimer's disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive...

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Main Authors: TAN, Chin Hong, HYMAN, Bradley T., TAN, Jacinth J. X., HESS, Christopher P., DILLON, William P., SCHELLENBERG, Gerard D., BESSER, Lilah M., KUKULL, Walter A., KAUPPI, Karolina, MCEVOY, Linda K., ANDREASSEN, Ole A., DALE, Anders M., FAN, Chun Chieh, DESIKAN, Rahul S.
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Language:English
Published: Institutional Knowledge at Singapore Management University 2017
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Online Access:https://ink.library.smu.edu.sg/soss_research/2744
https://ink.library.smu.edu.sg/context/soss_research/article/4001/viewcontent/Polygenic_hazard_scores_in_preclinical_Alzheimer_d__1_.pdf
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spelling sg-smu-ink.soss_research-40012021-11-05T02:57:12Z Polygenic hazard scores in preclinical Alzheimer's disease TAN, Chin Hong HYMAN, Bradley T. TAN, Jacinth J. X. HESS, Christopher P. DILLON, William P. SCHELLENBERG, Gerard D. BESSER, Lilah M. KUKULL, Walter A. KAUPPI, Karolina MCEVOY, Linda K. ANDREASSEN, Ole A. DALE, Anders M. FAN, Chun Chieh DESIKAN, Rahul S. Identifying asymptomatic older individuals at elevated risk for developing Alzheimer's disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE e4 carrier status. Older individuals in the highest PHS percentiles showed the highest AD incidence rates. PHS predicted longitudinal clinical decline among older individuals with moderate to high CERAD (amyloid) and Braak (tau) scores at autopsy, even among APOE e4 non-carriers. Beyond APOE, PHS may help identify asymptomatic individuals at highest risk for developing Alzheimer's neurodegeneration. 2017-09-01T07:00:00Z text application/pdf https://ink.library.smu.edu.sg/soss_research/2744 info:doi/10.1002/ana.25029 https://ink.library.smu.edu.sg/context/soss_research/article/4001/viewcontent/Polygenic_hazard_scores_in_preclinical_Alzheimer_d__1_.pdf http://creativecommons.org/licenses/by-nc-nd/4.0/ Research Collection School of Social Sciences eng Institutional Knowledge at Singapore Management University Polygenic risk Preclinical AD Diseases Psychology
institution Singapore Management University
building SMU Libraries
continent Asia
country Singapore
Singapore
content_provider SMU Libraries
collection InK@SMU
language English
topic Polygenic risk
Preclinical AD
Diseases
Psychology
spellingShingle Polygenic risk
Preclinical AD
Diseases
Psychology
TAN, Chin Hong
HYMAN, Bradley T.
TAN, Jacinth J. X.
HESS, Christopher P.
DILLON, William P.
SCHELLENBERG, Gerard D.
BESSER, Lilah M.
KUKULL, Walter A.
KAUPPI, Karolina
MCEVOY, Linda K.
ANDREASSEN, Ole A.
DALE, Anders M.
FAN, Chun Chieh
DESIKAN, Rahul S.
Polygenic hazard scores in preclinical Alzheimer's disease
description Identifying asymptomatic older individuals at elevated risk for developing Alzheimer's disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE e4 carrier status. Older individuals in the highest PHS percentiles showed the highest AD incidence rates. PHS predicted longitudinal clinical decline among older individuals with moderate to high CERAD (amyloid) and Braak (tau) scores at autopsy, even among APOE e4 non-carriers. Beyond APOE, PHS may help identify asymptomatic individuals at highest risk for developing Alzheimer's neurodegeneration.
format text
author TAN, Chin Hong
HYMAN, Bradley T.
TAN, Jacinth J. X.
HESS, Christopher P.
DILLON, William P.
SCHELLENBERG, Gerard D.
BESSER, Lilah M.
KUKULL, Walter A.
KAUPPI, Karolina
MCEVOY, Linda K.
ANDREASSEN, Ole A.
DALE, Anders M.
FAN, Chun Chieh
DESIKAN, Rahul S.
author_facet TAN, Chin Hong
HYMAN, Bradley T.
TAN, Jacinth J. X.
HESS, Christopher P.
DILLON, William P.
SCHELLENBERG, Gerard D.
BESSER, Lilah M.
KUKULL, Walter A.
KAUPPI, Karolina
MCEVOY, Linda K.
ANDREASSEN, Ole A.
DALE, Anders M.
FAN, Chun Chieh
DESIKAN, Rahul S.
author_sort TAN, Chin Hong
title Polygenic hazard scores in preclinical Alzheimer's disease
title_short Polygenic hazard scores in preclinical Alzheimer's disease
title_full Polygenic hazard scores in preclinical Alzheimer's disease
title_fullStr Polygenic hazard scores in preclinical Alzheimer's disease
title_full_unstemmed Polygenic hazard scores in preclinical Alzheimer's disease
title_sort polygenic hazard scores in preclinical alzheimer's disease
publisher Institutional Knowledge at Singapore Management University
publishDate 2017
url https://ink.library.smu.edu.sg/soss_research/2744
https://ink.library.smu.edu.sg/context/soss_research/article/4001/viewcontent/Polygenic_hazard_scores_in_preclinical_Alzheimer_d__1_.pdf
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