Polygenic hazard scores in preclinical Alzheimer's disease
Identifying asymptomatic older individuals at elevated risk for developing Alzheimer's disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive...
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sg-smu-ink.soss_research-40012021-11-05T02:57:12Z Polygenic hazard scores in preclinical Alzheimer's disease TAN, Chin Hong HYMAN, Bradley T. TAN, Jacinth J. X. HESS, Christopher P. DILLON, William P. SCHELLENBERG, Gerard D. BESSER, Lilah M. KUKULL, Walter A. KAUPPI, Karolina MCEVOY, Linda K. ANDREASSEN, Ole A. DALE, Anders M. FAN, Chun Chieh DESIKAN, Rahul S. Identifying asymptomatic older individuals at elevated risk for developing Alzheimer's disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE e4 carrier status. Older individuals in the highest PHS percentiles showed the highest AD incidence rates. PHS predicted longitudinal clinical decline among older individuals with moderate to high CERAD (amyloid) and Braak (tau) scores at autopsy, even among APOE e4 non-carriers. Beyond APOE, PHS may help identify asymptomatic individuals at highest risk for developing Alzheimer's neurodegeneration. 2017-09-01T07:00:00Z text application/pdf https://ink.library.smu.edu.sg/soss_research/2744 info:doi/10.1002/ana.25029 https://ink.library.smu.edu.sg/context/soss_research/article/4001/viewcontent/Polygenic_hazard_scores_in_preclinical_Alzheimer_d__1_.pdf http://creativecommons.org/licenses/by-nc-nd/4.0/ Research Collection School of Social Sciences eng Institutional Knowledge at Singapore Management University Polygenic risk Preclinical AD Diseases Psychology |
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Polygenic risk Preclinical AD Diseases Psychology TAN, Chin Hong HYMAN, Bradley T. TAN, Jacinth J. X. HESS, Christopher P. DILLON, William P. SCHELLENBERG, Gerard D. BESSER, Lilah M. KUKULL, Walter A. KAUPPI, Karolina MCEVOY, Linda K. ANDREASSEN, Ole A. DALE, Anders M. FAN, Chun Chieh DESIKAN, Rahul S. Polygenic hazard scores in preclinical Alzheimer's disease |
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Identifying asymptomatic older individuals at elevated risk for developing Alzheimer's disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE e4 carrier status. Older individuals in the highest PHS percentiles showed the highest AD incidence rates. PHS predicted longitudinal clinical decline among older individuals with moderate to high CERAD (amyloid) and Braak (tau) scores at autopsy, even among APOE e4 non-carriers. Beyond APOE, PHS may help identify asymptomatic individuals at highest risk for developing Alzheimer's neurodegeneration. |
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TAN, Chin Hong HYMAN, Bradley T. TAN, Jacinth J. X. HESS, Christopher P. DILLON, William P. SCHELLENBERG, Gerard D. BESSER, Lilah M. KUKULL, Walter A. KAUPPI, Karolina MCEVOY, Linda K. ANDREASSEN, Ole A. DALE, Anders M. FAN, Chun Chieh DESIKAN, Rahul S. |
author_facet |
TAN, Chin Hong HYMAN, Bradley T. TAN, Jacinth J. X. HESS, Christopher P. DILLON, William P. SCHELLENBERG, Gerard D. BESSER, Lilah M. KUKULL, Walter A. KAUPPI, Karolina MCEVOY, Linda K. ANDREASSEN, Ole A. DALE, Anders M. FAN, Chun Chieh DESIKAN, Rahul S. |
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TAN, Chin Hong |
title |
Polygenic hazard scores in preclinical Alzheimer's disease |
title_short |
Polygenic hazard scores in preclinical Alzheimer's disease |
title_full |
Polygenic hazard scores in preclinical Alzheimer's disease |
title_fullStr |
Polygenic hazard scores in preclinical Alzheimer's disease |
title_full_unstemmed |
Polygenic hazard scores in preclinical Alzheimer's disease |
title_sort |
polygenic hazard scores in preclinical alzheimer's disease |
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Institutional Knowledge at Singapore Management University |
publishDate |
2017 |
url |
https://ink.library.smu.edu.sg/soss_research/2744 https://ink.library.smu.edu.sg/context/soss_research/article/4001/viewcontent/Polygenic_hazard_scores_in_preclinical_Alzheimer_d__1_.pdf |
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1770574488348393472 |