Polygenic hazard scores in preclinical Alzheimer's disease

• Main Authors: TAN, Chin Hong, HYMAN, Bradley T., TAN, Jacinth J. X., HESS, Christopher P., DILLON, William P., SCHELLENBERG, Gerard D., BESSER, Lilah M., KUKULL, Walter A., KAUPPI, Karolina, MCEVOY, Linda K., ANDREASSEN, Ole A., DALE, Anders M., FAN, Chun Chieh, DESIKAN, Rahul S.
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2017
• Subjects: Polygenic risk; Preclinical AD; Diseases; Psychology
• Online Access: https://ink.library.smu.edu.sg/soss_research/2744; https://ink.library.smu.edu.sg/context/soss_research/article/4001/viewcontent/Polygenic_hazard_scores_in_preclinical_Alzheimer_d__1_.pdf
• Institution: Singapore Management University

Identifying asymptomatic older individuals at elevated risk for developing Alzheimer's disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive...