Polygenic hazard scores in preclinical Alzheimer's disease

• المؤلفون الرئيسيون: TAN, Chin Hong, HYMAN, Bradley T., TAN, Jacinth J. X., HESS, Christopher P., DILLON, William P., SCHELLENBERG, Gerard D., BESSER, Lilah M., KUKULL, Walter A., KAUPPI, Karolina, MCEVOY, Linda K., ANDREASSEN, Ole A., DALE, Anders M., FAN, Chun Chieh, DESIKAN, Rahul S.
• التنسيق: text
• اللغة: English
• منشور في: Institutional Knowledge at Singapore Management University 2017
• الموضوعات: Polygenic risk; Preclinical AD; Diseases; Psychology
• الوصول للمادة أونلاين: https://ink.library.smu.edu.sg/soss_research/2744; https://ink.library.smu.edu.sg/context/soss_research/article/4001/viewcontent/Polygenic_hazard_scores_in_preclinical_Alzheimer_d__1_.pdf

Identifying asymptomatic older individuals at elevated risk for developing Alzheimer's disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive...