Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1

• Main Authors: Phromnoi K., Prasad S., Gupta S., Kannappan R., Reuter S., Limtrakul P., Aggarwal B.B.
• 格式: Article
• 語言: English
• 出版: 2014
• 在線閱讀: http://www.scopus.com/inward/record.url?eid=2-s2.0-80054782411&partnerID=40&md5=025491561290998f19eed72532257715; http://cmuir.cmu.ac.th/handle/6653943832/3712

Because constitutive activation of signal transducers and activators of transcription-3 (STAT3) has been linked with cellular transformation, survival, proliferation, chemoresistance, and angiogenesis of various tumor cells, agents that can suppress STAT3 activation have potential as cancer therapeu...