Analysis of pharmaceutical heparins and potential contaminants using<sup>1</sup>H-NMR and PAGE
In 2008, heparin (active pharmaceutical ingredient, API) lots were associated with anaphylactoid-type reactions. Oversulfated chondroitin sulfate (OSCS), a semi-synthetic glycosaminoglycan (GAG), was identified as a contaminant and dermatan sulfate (DS) as an impurity. While DS has no known toxicity...
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| Main Authors: | , , , , , , , |
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| Format: | Journal |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349648765&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59930 |
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| Institution: | Chiang Mai University |