Investigation of splicing changes and post-translational processing of LMNA in sporadic inclusion body myositis

• المؤلفون الرئيسيون: Yue Bei Luo, Chalermchai Mitrpant, Russell Johnsen, Vicki Fabian, Merrilee Needham, Sue Fletcher, Steve D. Wilton, Frank L. Mastaglia
• مؤلفون آخرون: University of Western Australia
• التنسيق: مقال
• منشور في: 2018
• الموضوعات: Medicine
• الوصول للمادة أونلاين: https://repository.li.mahidol.ac.th/handle/123456789/32110
• المؤسسة: Mahidol University

Some features of sporadic inclusion body myositis (s-IBM) suggest that there is acceleration of the normal ageing process in muscle tissue. LMNA encodes the nuclear lamina proteins lamin A/C through alternative splicing, and aberrant splicing of exon 11 leads to the premature ageing disease, Hutchin...