Investigation of splicing changes and post-translational processing of LMNA in sporadic inclusion body myositis

• Main Authors: Yue Bei Luo, Chalermchai Mitrpant, Russell Johnsen, Vicki Fabian, Merrilee Needham, Sue Fletcher, Steve D. Wilton, Frank L. Mastaglia
• Other Authors: University of Western Australia
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/32110
• Institution: Mahidol University

Some features of sporadic inclusion body myositis (s-IBM) suggest that there is acceleration of the normal ageing process in muscle tissue. LMNA encodes the nuclear lamina proteins lamin A/C through alternative splicing, and aberrant splicing of exon 11 leads to the premature ageing disease, Hutchin...