Functional chromatin features are associated with structural mutations in cancer

by Grzeda K.R., Royer-Bertrand B., Inaki K., Kim H., Hillmer A.M., Liu E.T., Chuang J.H.
Published 2018

Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: A potential role for homoserine kinase in insect-stage Trypanosoma brucei

by Mohamed Suhaimi N.-A., Foong Y.M., Lee D.Y.S., Phyo W.M., Cima I., Lee E.X.W., Goh W.L., Lim W.-Y., Chia K.S., Kong S.L., Gong M., Lim B., Hillmer A.M., Koh P.K., Ying J.Y., Tan M.-H.
Published 2016

TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome

by Ribi, S, Baumhoer, D, Lee, K, Edison, Teo, A.S, Madan, B, Zhang, K, Kohlmann, W.K, Yao, F, Lee, W.H, Hoi, Q, Cai, S, Woo, X.Y, Tan, P, Jundt, G, Smida, J, Nathrath, M, Sung, W.-K, Schiffman, J.D, Virshup, D.M, Hillmer, A.M
Published 2016

High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer

by Tan I.B., Malik S., Ramnarayanan K., McPherson J.R., Ho D.L., Suzuki Y., Ng S.B., Yan S., Lim K.H., Koh D., Hoe C.M., Chan C.Y., Ten R., Goh B.K.P., Chung A.Y.F., Tan J., Chan C.X., Tay S.T., Alexander L., Nagarajan N., Hillmer A.M., Tang C.L., Chua C., Teh B.T., Rozen S., Tan P.
Published 2018

Long Span DNA Paired-End-Tag (DNA-PET) Sequencing Strategy for the Interrogation of Genomic Structural Mutations and Fusion-Point-Guided Reconstruction of Amplicons

by Yao, F., Ariyaratne, P.N., Hillmer, A.M., Lee, W.H., Li, G., Teo, A.S.M., Woo, X.Y., Zhang, Z., Chen, J.P., Poh, W.T., Zawack, K.F.B., Chan, C.S., Leong, S.T., Neo, S.C., Choi, P.S.D., Gao, S., Nagarajan, N., Thoreau, H., Shahab, A., Ruan, X., Cacheux-Rataboul, V., Wei, C.-L., Bourque, G., Sung, W.-K., Liu, E.T., Ruan, Y.
Published 2014

Detection of chromosomal breakpoints in patients with developmental delay and speech disorders

by Utami K.H., Hillmer A.M., Aksoy I., Chew E.G.Y., Teo A.S.M., Zhang Z., Lee C.W.H., Chen P.J., Seng C.C., Ariyaratne P.N., Rouam S.L., Soo L.S., Yousoof S., Prokudin I., Peters G., Collins F., Wilson M., Kakakios A., Haddad G., Menuet A., Perche O., Tay S.K.H., Sung K.W.K., Ruan X., Ruan Y., Liu E.T., Briault S., Jamieson R.V., Davila S., Cacheux V.
Published 2018

Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing

by Nahar, R, Zhai, W, Zhang, T, Takano, A, Khng, A.J, Lee, Y.Y, Liu, X, Lim, C.H, Koh, T.P.T, Aung, Z.W, Lim, T.K.H, Veeravalli, L, Yuan, J, Teo, A.S.M, Chan, C.X, Poh, H.M, Chua, I.M.L, Liew, A.A, Lau, D.P.X, Kwang, X.L, Toh, C.K, Lim, W.-T, Lim, B, Tam, W.L, Tan, E.-H, Hillmer, A.M, Tan, D.S.W
Published 2020

Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity

by Ooi, W.F, Xing, M, Xu, C, Yao, X, Ramlee, M.K, Lim, M.C, Cao, F, Lim, K, Babu, D, Poon, L.-F, Lin Suling, J, Qamra, A, Irwanto, A, Qu Zhengzhong, J, Nandi, T, Lee-Lim, A.P, Chan, Y.S, Tay, S.T, Lee, M.H, Davies, J.O.J, Wong, W.K, Soo, K.C, Chan, W.H, Ong, H.S, Chow, P, Wong, C.Y, Rha, S.Y, Liu, J, Hillmer, A.M, Hughes, J.R, Rozen, S, Teh, B.T, Fullwood, M.J, Li, S, Tan, P
Published 2020

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

by Zang, Z.J., Cutcutache, I., Poon, S.L., Zhang, S.L., Mcpherson, J.R., Tao, J., Rajasegaran, V., Heng, H.L., Deng, N., Gan, A., Lim, K.H., Ong, C.K., Huang, D., Chin, S.Y., Tan, I.B., Ng, C.C.Y., Yu, W., Wu, Y., Lee, M., Wu, J., Poh, D., Wan, W.K., Rha, S.Y., So, J., Salto-Tellez, M., Yeoh, K.G., Wong, W.K., Zhu, Y.-J., Futreal, P.A., Pang, B., Ruan, Y., Hillmer, A.M., Bertrand, D., Nagarajan, N., Rozen, S., Teh, B.T., Tan, P.
Published 2013

Whole-genome reconstruction and mutational signatures in gastric cancer

by Nagarajan N., Bertrand D., Hillmer A.M., Zang Z.J., Yao F., Jacques P., Teo A.S., Cutcutache I., Zhang Z., Lee W.H., Sia Y.Y., Gao S., Ariyaratne P.N., Ho A., Woo X.Y., Veeravali L., Ong C.K., Deng N., Desai K.V., Khor C.C., Hibberd M.L., Shahab A., Rao J., Wu M., Teh M., Zhu F., Chin S.Y., Pang B., So J.B., Bourque G., Soong R., Sung W.-K., Tean Teh B., Rozen S., Ruan X., Yeoh K.G., Tan P.B., Ruan Y.
Published 2018

Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes

by Hillmer, A.M., Yao, F., Inaki, K., Lee, W.H., Ariyaratne, P.N., Teo, A.S.M., Woo, X.Y., Zhang, Z., Zhao, H., Ukil, L., Chen, J.P., Zhu, F., So, J.B.Y., Salto-Tellez, M., Poh, W.T., Zawack, K.F.B., Nagarajan, N., Gao, S., Li, G., Kumar, V., Lim, H.P.J., Sia, Y.Y., Chan, C.S., Leong, S.T., Neo, S.C., Choi, P.S.D., Thoreau, H., Tan, P.B.O., Shahab, A., Ruan, X., Bergh, J., Hall, P., Cacheux-Rataboul, V., Wei, C.-L., Yeoh, K.G., Sung, W.-K., Bourque, G., Liu, E.T., Ruan, Y.
Published 2014

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

by Ng, K.P., Hillmer, A.M., Chuah, C.T.H., Juan, W.C., Ko, T.K., Teo, A.S.M., Ariyaratne, P.N., Takahashi, N., Sawada, K., Fei, Y., Soh, S., Lee, W.H., Huang, J.W.J., Allen Jr., J.C., Woo, X.Y., Nagarajan, N., Kumar, V., Thalamuthu, A., Poh, W.T., Ang, A.L., Mya, H.T., How, G.F., Yang, L.Y., Koh, L.P., Chowbay, B., Chang, C.-T., Nadarajan, V.S., Chng, W.J., Than, H., Lim, L.C., Goh, Y.T., Zhang, S., Poh, D., Tan, P., Seet, J.-E., Ang, M.-K., Chau, N.-M., Ng, Q.-S., Tan, D.S.W., Soda, M., Isobe, K., Nöthen, M.M., Wong, T.Y., Shahab, A., Ruan, X., Cacheux-Rataboul, V., Sung, W.-K., Tan, E.H., Yatabe, Y., Mano, H., Soo, R.A., Chin, T.M., Lim, W.-T., Ruan, Y., Ong, S.T.
Published 2014