Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP

by Nizetic, Dean, Chen, Christopher L., Hong, Wanjin, Koo, Edward H.
Published 2016

Chronic cerebral hypoperfusion alters the CypA-EMMPRIN-gelatinase pathway: Implications for vascular dementia

by Chai, Yuek Ling, Rajeev, Vismitha, Poh, Luting, Selvaraji, Sharmelee, Hilal, Saima, Chen, Christopher P, Jo, Dong-Gyu, Koo, Edward H, Arumugam, Thiruma, Lai, Mitchell KP
Published 2023

The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy

by HO, WAN YUN, TAI, YEE KIT, CHANG, JER-CHERNG, LIANG, JASON, TYAN, SHEUE-HOUY, CHEN, SONG, GUAN, JUN-LIN, ZHOU, HUILIN, SHEN, HAN-MING, KOO, EDWARD, LING, SHUO-CHIEN
Published 2019

Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke

by Poh, Luting, Kang, Sung-Wook, Baik, Sang-Ha, Ng, Gavin Yong Quan, She, David T, Balaganapathy, Priyanka, Dheen, S Thameem, Magnus, Tim, Gelderblom, Mathias, Sobey, Christopher G, Koo, Edward H, Fann, David Y, Arumugam, Thiruma V
Published 2020

Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits

by Ho, Wan Yun, Agrawal, Ira, Tyan, Sheue-Houy, Sanford, Emma, Chang, Wei-Tang, Lim, Kenneth, Ong, Jolynn, Tan, Bernice Siu Yan, Moe, Aung Aung Kywe, Yu, Regina, Wong, Peiyan, Tucker-Kellogg, Greg, Koo, Edward, Chuang, Kai-Hsiang, Ling, Shuo-Chien
Published 2022

FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons

by Ho, Wan Yun, Chak, Li-Ling, Hor, Jin-Hui, Liu, Fujia, Diaz-Garcia, Sandra, Chang, Jer-Cherng, Sanford, Emma, Rodriguez, Maria J., Alagappan, Durgadevi, Lim, Su Min, Cho, Yik-Lam, Shimizu, Yuji, Sun, Alfred Xuyang, Tyan, Sheue-Houy, Koo, Edward, Kim, Seung Hyun, Ravits, John, Ng, Shi-Yan, Okamura, Katsutomo, Ling, Shuo-Chien
Published 2024