The pro-regenerative effects of hyperil6 in drug induced liver injury are unexpectedly due to competitive inhibition of il11 signaling

by Dong, Jinrui, Viswanathan, Sivakumar, Adami, Eleonora, Schafer, Sebastian, Kuthubudeen, Fathima F., Widjaja, Anissa A., Cook, Stuart A.
Published 2022

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts

by Widjaja, Anissa A, Viswanathan, Sivakumar, Jinrui, Dong, Singh, Brijesh K, Tan, Jessie, Ting, Joyce Goh Wei, Lamb, David, Shekeran, Shamini G, George, Benjamin L, Schafer, Sebastian, Carling, David, Adami, Eleonora, Cook, Stuart A
Published 2022

Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis

by Ng, Benjamin, Widjaja, Anissa A., Viswanathan, Sivakumar, Dong, Jinrui, Chothani, Sonia P., Lim, Stella, Shekeran, Shamini G., Tan, Jessie, McGregor, Narelle E., Walker, Emma C., Sims, Natalie A., Schafer, Sebastian, Cook, Stuart A.
Published 2022

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

by Widjaja, Anissa A, Viswanathan, Sivakumar, Shekeran, Shamini G, Adami, Eleonora, Lim, Wei-Wen, Chothani, Sonia, Tan, Jessie, Goh, Joyce Wei Ting, Chen, Hui Mei, Lim, Sze Yun, Boustany-Kari, Carine M, Hawkins, Julie, Petretto, Enrico, Huebner, Norbert, Schafer, Sebastian, Coffman, Thomas M, Cook, Stuart A
Published 2023

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

by Dong, Jinrui, Viswanathan, Sivakumar, Adami, Eleonora, Singh, Brijesh K, Chothani, Sonia P, Ng, Benjamin, Lim, Wei Wen, Zhou, Jin, Tripathi, Madhulika, Ko, Nicole SJ, Shekeran, Shamini G, Tan, Jessie, Lim, Sze Yun, Wang, Mao, Lio, Pei Min, Yen, Paul M, Schafer, Sebastian, Cook, Stuart A, Widjaja, Anissa A
Published 2022

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

by Widjaja, Anissa A, Dong, Jinrui, Adami, Eleonora, Viswanathan, Sivakumar, Ng, Benjamin, Pakkiri, Leroy S, Chothani, Sonia P, Singh, Brijesh K, Lim, Wei Wen, Zhou, Jin, Shekeran, Shamini G, Tan, Jessie, Lim, Sze Yun, Goh, Joyce, Wang, Mao, Holgate, Robert, Hearn, Arron, Felkin, Leanne E, Yen, Paul M, Dear, James W, Drum, Chester L, Schafer, Sebastian, Cook, Stuart A
Published 2022

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis.

by Widjaja, Anissa A, Singh, Brijesh K, Adami, Eleonora, Viswanathan, Sivakumar, Dong, Jinrui, D'Agostino, Giuseppe A, Ng, Benjamin, Lim, Wei Wen, Tan, Jessie, Paleja, Bhairav S, Tripathi, Madhulika, Lim, Sze Yun, Shekeran, Shamini Guna, Chothani, Sonia P, Rabes, Anne, Sombetzki, Martina, Bruinstroop, Eveline, Min, Lio Pei, Sinha, Rohit A, Albani, Salvatore, Yen, Paul M, Schafer, Sebastian, Cook, Stuart A
Published 2019

Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (Nature Communications, (2020), 11, 1, (2523), 10.1038/s41467...

by Whiffin, Nicola, Karczewski, Konrad J., Zhang, Xiaolei, Chothani, Sonia, Smith, Miriam J., Evans, D. Gareth, Roberts, Angharad M., Quaife, Nicholas M., Schafer, Sebastian, Rackham, Owen, Alföldi, J., O’Donnell-Luria, A.H., Francioli, Laurent C., Armean, Irina M., Banks, E., Bergelson, L., Cibulskis, K., Collins, R.L., Connolly, K.M., Covarrubias, M., Cummings, B., Daly, M.J., Donnelly, S., Farjoun, Y., Ferriera, S., Gabriel, S., Gauthier, L.D., Gentry, J., Gupta, N., Jeandet, T., Kaplan, D., Laricchia, K.M., Llanwarne, C., Minikel, E.V., Munshi, R., Neale, B.M., Novod, S., Petrillo, N., Poterba, T., Roazen, D., Ruano-Rubio, V., Saltzman, A., Samocha, K.E., Schleicher, M., Seed, C., Solomonson, M., Soto, J., Tiao, G., Tibbetts, K., Tolonen, C., Vittal, C., Wade, G., Wang, A., Wang, Q., Watts, N.A., Weisburd, B., Aguilar Salinas, Carlos A., Ahmad, T., Albert, C.M., Ardissino, D., Atzmon, G., Barnard, J., Beaugerie, L., Benjamin, E.J., Boehnke, M., Bonnycastle, L.L., Bottinger, E.P., Bowden, D.W., Bown, M.J., Chambers, J.C., Chan, J.C., Chasman, D., Cho, J., Chung, M.K., Cohen, B., Correa, A., Dabelea, D., Daly, M.J., Darbar, D., Duggirala, R., Dupuis, J., Ellinor, P.T., Elosua, R., Erdmann, J., Esko, T., Färkkilä, M., Florez, J., Programs in Metabolism and Medical and Population Genetics, Broad Institute., Department of Medicine, Harvard Medical School, Boston, MA 02115, United States., Franke, A., Getz, G., Glaser, B., Glatt, S.J., Goldstein, D., Gonzalez, C., Groop, L., Haiman, C., Hanis, C., Harms, M., Hiltunen, M., Holi, M.M., Hultman, C.M., Kallela, M., Kaprio, J., Kathiresan, S., Kim, B.-J., Kim, Y.J., Kirov, G., Kooner, J., Koskinen, S., Krumholz, H.M., Kugathasan, S., Kwak, S.H., Laakso, M., Lehtimäki, T., Loos, R.J.F., Lubitz, S.A., Ma, R.C.W., Marrugat, J., Mattila, K.M., McCarroll, S., McCarthy, M.I., McGovern, D., McPherson, R., Meigs, J.B., Melander, O., Metspalu, A., Neale, B.M., Nilsson, P.M., O’Donovan, M.C., Ongur, D., Orozco, L., Owen, M.J., Palmer, C.N.A., Palotie, A., Park, K.S., Pato, C., Pulver, A.E., Rahman, N., Remes, A.M., Rioux, J.D., Ripatti, S., Roden, D.M., Saleheen, D., Salomaa, V., Samani, N.J., Scharf, J., Schunkert, H., Shoemaker, M.B., Sklar, P., Soininen, H., Sokol, H., Spector, T., Sullivan, P.F., Suvisaari, J., Tai, E. Shyong, Teo, Yik Ying, Tiinamaija, T., Tsuang, M., Turner, D., Tusie-Luna, T., Vartiainen, E., Watkins, H., Weersma, R.K., Wessman, M., Wilson, J.G., Xavier, R.J., Vawter, M.P., Cook, Stuart A., Barton, Paul J. R., MacArthur, Daniel G., Ware, James S.
Published 2022