An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions

• Main Authors: Lim, Yan Ting, Prabhu, Nayana, Dai, Lingyun, Go, Ka Diam, Chen, Dan, Sreekumar, Lekshmy, Egeblad, Louise, Eriksson, Staffan, Chen, Liyan, Veerappan, Saranya, Teo, Hsiang Ling, Tan, Chris Soon Heng, Lengqvist, Johan, Larsson, Andreas, Sobota, Radoslaw M., Nordlund, Pär
• Other Authors: Lau, Andy T. Y.
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences; Metabolite; Protein-nucleotide Interactions
• Online Access: https://hdl.handle.net/10356/103402; http://hdl.handle.net/10220/47307
• Institution: Nanyang Technological University

Metabolite-protein interactions define the output of metabolic pathways and regulate many cellular processes. Although diseases are often characterized by distortions in metabolic processes, efficient means to discover and study such interactions directly in cells have been lacking. A stringent impl...