Single-molecule mechanical folding and unfolding of RNA hairpins : effects of single A-U to A·C pair substitutions and single proton binding and implications for mRNA structure-induced -1 ribosomal frameshifting
A wobble A·C pair can be protonated at near physiological pH to form a more stable wobble A+·C pair. Here, we constructed an RNA hairpin (rHP) and three mutants with one A-U base pair substituted with an A·C mismatch on the top (near the loop, U22C), middle (U25C), and bottom (U29C) positions of the...
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Main Authors: | Yang, Lixia, Zhong, Zhensheng, Tong, Cailing, Jia, Huan, Liu, Yiran, Chen, Gang |
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Other Authors: | School of Physical and Mathematical Sciences |
Format: | Article |
Language: | English |
Published: |
2019
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/105583 http://hdl.handle.net/10220/50141 |
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Institution: | Nanyang Technological University |
Language: | English |
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