The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance interferon-β response

• Main Authors: Kim, Susana Soo-Yeon, Sze, Lynette, Lam, Kong-Peng
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2019
• 主題: Innate Immunity; Viral Immunology; Science::Biological sciences
• 在線閱讀: https://hdl.handle.net/10356/106405; http://hdl.handle.net/10220/49627
• 機構: Nanyang Technological University

RIG-I senses viral RNA in the cytosol and initiates host innate immune response by triggering the production of type 1 interferon. A recent RNAi knockdown screen yielded close to hundred host genes whose products affected viral RNA-induced IFN-β production and highlighted the complexity of the antiv...