The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance interferon-β response

• المؤلفون الرئيسيون: Kim, Susana Soo-Yeon, Sze, Lynette, Lam, Kong-Peng
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Innate Immunity; Viral Immunology; Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/106405; http://hdl.handle.net/10220/49627

RIG-I senses viral RNA in the cytosol and initiates host innate immune response by triggering the production of type 1 interferon. A recent RNAi knockdown screen yielded close to hundred host genes whose products affected viral RNA-induced IFN-β production and highlighted the complexity of the antiv...