Sequence- and structure-specific targeting of RNAs by short nucleobase-modified dsRNA-Binding PNAs Incorporating A-U pair-recognizing fluorescent light-up benzothiophene uracil and G-C pair-recognizing guanidinium

The structures of RNAs determine their functions including protein coding, catalysis, and gene regulation. RNAs are emerging as important therapeutic targets and diagnosis biomarkers. Compared to targeting RNAs through duplex formation, targeting the pre-formed dsRNA regions through structure-specif...

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Bibliographic Details
Main Author: Shivakumar Krishna Manchugondanahalli
Other Authors: Chen Gang
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2020
Subjects:
Online Access:https://hdl.handle.net/10356/137354
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Institution: Nanyang Technological University
Language: English