Sequence- and structure-specific targeting of RNAs by short nucleobase-modified dsRNA-Binding PNAs Incorporating A-U pair-recognizing fluorescent light-up benzothiophene uracil and G-C pair-recognizing guanidinium
The structures of RNAs determine their functions including protein coding, catalysis, and gene regulation. RNAs are emerging as important therapeutic targets and diagnosis biomarkers. Compared to targeting RNAs through duplex formation, targeting the pre-formed dsRNA regions through structure-specif...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2020
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| Online Access: | https://hdl.handle.net/10356/137354 |
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| Institution: | Nanyang Technological University |
| Language: | English |