Sequence- and structure-specific targeting of RNAs by short nucleobase-modified dsRNA-Binding PNAs Incorporating A-U pair-recognizing fluorescent light-up benzothiophene uracil and G-C pair-recognizing guanidinium

• Main Author: Shivakumar Krishna Manchugondanahalli
• Other Authors: Chen Gang
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Science::Chemistry
• Online Access: https://hdl.handle.net/10356/137354
• Institution: Nanyang Technological University

The structures of RNAs determine their functions including protein coding, catalysis, and gene regulation. RNAs are emerging as important therapeutic targets and diagnosis biomarkers. Compared to targeting RNAs through duplex formation, targeting the pre-formed dsRNA regions through structure-specif...