Access to chiral HWE reagents by rhodium-catalyzed asymmetric arylation of γ,δ-unsaturated β-ketophosphonates

• Main Authors: Yin, Long, Zhang, Dewei, Xing, Junhao, Wang, Yuhan, Wu, Changhui, Lu, Tao, Chen, Yadong, Hayashi, Tamio, Dou, Xiaowei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Stereoselectivity; Catalysts
• Online Access: https://hdl.handle.net/10356/139657
• Institution: Nanyang Technological University

Asymmetric arylation of γ,δ-unsaturated β-ketophosphonates with arylboronic acids is reported. By using the (R)-diene* ligated rhodium(I) chloride complex as a catalyst under none basic conditions, the corresponding β-ketophosphonates bearing a δ-chiral center were obtained in high yields (up to 99%...