HCAR1/MCT1 regulates tumor ferroptosis through the lactate-mediated AMPK-SCD1 activity and its therapeutic implications

• Main Authors: Zhao, Youbo, Li, Menghuan, Yao, Xuemei, Fei, Yang, Lin, Zhenghong, Li, Zhengguo, Cai, Kaiyong, Zhao, Yanli, Luo, Zhong
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Lactate; Ferroptosis
• Online Access: https://hdl.handle.net/10356/146149
• Institution: Nanyang Technological University

Ferroptosis is a recently discovered form of programed cell death caused by the metabolically regulated lipid peroxidation and holds promise for cancer treatment, but its regulatory mechanisms remain elusive. In this study, we observe that lactate-rich liver cancer cells exhibit enhanced resistance...