Structural determinants for peptide-bond formation by asparaginyl ligases

• Main Authors: Hemu, Xinya, El Sahili, Abbas, Hu, Side, Wong, Kaho, Chen, Yu, Wong, Yee Hwa, Zhang, Xiaohong, Serra, Aida, Goh, Boon Chong, Darwis, Dina Amallia, Chen, Ming Wei, Sze, Siu Kwan, Liu, Chuan-Fa, Lescar, Julien, Tam, James P.
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Science; Asparaginyl Ligase; Cyclopeptide
• 在線閱讀: https://hdl.handle.net/10356/148284

Asparaginyl endopeptidases (AEPs) are cysteine proteases which break Asx (Asn/Asp)-Xaa bonds in acidic conditions. Despite sharing a conserved overall structure with AEPs, certain plant enzymes such as butelase 1 act as a peptide asparaginyl ligase (PAL) and catalyze Asx-Xaa bond formation in near-n...