Syntheses and structure–activity relationships of N-phenethyl-quinazolin-4-yl-amines as potent inhibitors of cytochrome bd oxidase in Mycobacterium tuberculosis

• Main Authors: Hopfner, Sarah M., Lee, Bei Shi, Kalia, Nitin P., Miller Marvin J., Pethe, Kevin, Moraski, Garrett C.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Tuberculosis; Drug Development
• Online Access: https://hdl.handle.net/10356/153933
• Institution: Nanyang Technological University

The development of cytochrome bd oxidase (cyt‐bd) inhibitors are needed for comprehensive termination of energy production in Mycobacterium tuberculosis (Mtb) to treat tuberculosis infections. Herein, we report on the structure‐activity‐relationships (SAR) of 22 new N‐phenethyl‐quinazolin‐4‐ yl‐amin...