Catalytic access to ferrocenyl phosphines bearing both planar and central chirality – A kinetic resolution approach via catalytic asymmetric P(III)–C bond formation

• Main Authors: Abdul Sadeer, Kojima, Tadayuki, Ng, Jia Sheng, Gan, Kennard Jun Hao, Chew, Renta Jonathan, Li, Yongxin, Pullarkat, Sumod Appukuttan
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Asymmetric; Hydrophosphination
• Online Access: https://hdl.handle.net/10356/154139
• Institution: Nanyang Technological University

A series of enantioenriched ferrocenyl monophosphines imbued with both central and planar chirality were obtained catalytically (80–99% ee) via the kinetic resolution of 1,2-disubstituted planar chiral ferrocenyl enone racemates. The synthetic approach utilized a chiral palladacycle to facilitate th...