Carbene-catalyzed activation of formyl-phenylacetic esters for access to chiral dihydroisoquinolinones

• المؤلفون الرئيسيون: Wu, Shuquan, Xu, Jun, Deng, Rui, Wang, Hongling, Chi, Robin Yonggui, Zheng, Pengcheng
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Chemistry; Substituents; Chemical Reactions
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/155070
• المؤسسة: Nanyang Technological University

A carbene-catalyzed reaction to synthesize chiral dihydroisoquinolinones via an o-quinodimethane (o-QDM) intermediate is disclosed. o-QDM reacts with cyclic sulfonic imines via annulation to afford highly enantioenriched dihydroisoquinolinone products. ESI-HRMS studies suggest a stepwise Mannich add...