Expression, purification and crystallization of DynE8 involved in the biosynthesis of an antitumor warhead.
Enediynes are natural products that catalyze DNA breakage and hence are potential anticancer drugs. The polyketide backbone of the enediyne warhead ring strucure is synthesized by enediyne polyketide synthases. In this work, the enediyne polyketide synthase for dynemicin, DYNE8, was expressed, purif...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2009
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| Online Access: | http://hdl.handle.net/10356/16344 |
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| Institution: | Nanyang Technological University |
| Language: | English |