Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the most devastating bacterial disease. Multidrug-resistant Mtb strains are spreading worldwide, underscoring the need for new anti-TB targets and inhibitors. The respiratory chain complexes, including the cytochrome bd oxidase (cyt-b...
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sg-ntu-dr.10356-1692552024-04-26T01:44:24Z Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery Harikishore, Amaravadhi Mathiyazakan, Vikneswaran Pethe, Kevin Grüber, Gerhard School of Biological Sciences Lee Kong Chian School of Medicine (LKCMedicine) Medicine, Health and Life Sciences Cytochrome bd oxidase Virulence Mycobacteria Tuberculosis Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the most devastating bacterial disease. Multidrug-resistant Mtb strains are spreading worldwide, underscoring the need for new anti-TB targets and inhibitors. The respiratory chain complexes, including the cytochrome bd oxidase (cyt-bd), have been identified as an attractive target for drug development. Recent novel structural and mechanistic insight as well as inhibitors of Mtb's cyt-bd brought this enzyme into the focus. National Research Foundation (NRF) Submitted/Accepted version The authors are supported by the National Research Foundation (NRF) Singapore, through the NRF Competitive Research Programme (CRP), Grant Award Number NRF-CRP27-2021-0002. 2023-07-10T06:38:32Z 2023-07-10T06:38:32Z 2023 Journal Article Harikishore, A., Mathiyazakan, V., Pethe, K. & Grüber, G. (2023). Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery. Expert Opinion On Drug Discovery, 18(8), 917-927. https://dx.doi.org/10.1080/17460441.2023.2224553 1746-0441 https://hdl.handle.net/10356/169255 10.1080/17460441.2023.2224553 37332221 2-s2.0-85162245248 8 18 917 927 en NRF-CRP27-2021-0002 Expert Opinion on Drug Discovery © 2023 Informa UK Limited, trading as Taylor & Francis Group. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1080/17460441.2023.2224553. application/pdf |
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Medicine, Health and Life Sciences Cytochrome bd oxidase Virulence Mycobacteria Tuberculosis |
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Medicine, Health and Life Sciences Cytochrome bd oxidase Virulence Mycobacteria Tuberculosis Harikishore, Amaravadhi Mathiyazakan, Vikneswaran Pethe, Kevin Grüber, Gerhard Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery |
| description |
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the most devastating bacterial disease. Multidrug-resistant Mtb strains are spreading worldwide, underscoring the need for new anti-TB targets and inhibitors. The respiratory chain complexes, including the cytochrome bd oxidase (cyt-bd), have been identified as an attractive target for drug development. Recent novel structural and mechanistic insight as well as inhibitors of Mtb's cyt-bd brought this enzyme into the focus. |
| author2 |
School of Biological Sciences |
| author_facet |
School of Biological Sciences Harikishore, Amaravadhi Mathiyazakan, Vikneswaran Pethe, Kevin Grüber, Gerhard |
| format |
Article |
| author |
Harikishore, Amaravadhi Mathiyazakan, Vikneswaran Pethe, Kevin Grüber, Gerhard |
| author_sort |
Harikishore, Amaravadhi |
| title |
Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery |
| title_short |
Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery |
| title_full |
Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery |
| title_fullStr |
Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery |
| title_full_unstemmed |
Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery |
| title_sort |
novel targets and inhibitors of the mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery |
| publishDate |
2023 |
| url |
https://hdl.handle.net/10356/169255 |
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1806059738504364032 |