Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex

Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex

An attractive approach to target intracellular macromolecular interfaces and to model putative drug interactions is to design small high-affinity proteins. Variable domains of the immunoglobulin heavy chain (VH domains) are ideal miniproteins, but their development has been restricted by poor intrac...

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Main Authors:	Frosi, Yuri, Lin, Yen-Chu, Jiang, Shimin, Ramlan, Siti Radhiah, Hew, Kelly, Engman, Alf Henrik, Pillai, Anil, Yeung, Kit, Cheng, Yue Xiang, Cornvik, Tobias, Nordlund, Par, Goh, Megan, Lama, Dilraj, Gates, Zachary P., Verma, Chandra Shekhar, Thean, Dawn, Lane, David P., Asial, Ignacio, Brown, Christopher J.
其他作者:	School of Biological Sciences
格式:	Article
語言:	English
出版:	2023
主題:	Engineering Cell Surface Display Techniques Eukaryotic Initiation Factor-4E
在線閱讀:	https://hdl.handle.net/10356/170835
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

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