Selective protein aggregation confines and inhibits endotoxins in wounds: linking host defense to amyloid formation

• Main Authors: Petrlova, Jitka, Hartman, Erik, Petruk, Ganna, Lim, Jeremy Chun Hwee, Adav, Sunil Shankar, Kjellström, Sven, Puthia, Manoj, Schmidtchen, Artur
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2024
• Subjects: Engineering; Bacteriology; Immunology
• Online Access: https://hdl.handle.net/10356/173914
• Institution: Nanyang Technological University

Bacterial lipopolysaccharide (LPS) induces rapid protein aggregation in human wound fluid. We aimed to characterize these LPS-induced aggregates and their functional implications using a combination of mass spectrometry analyses, biochemical assays, biological imaging, cell experiments, and animal m...