Four additional natural 7-deazaguanine derivatives in phages and how to make them

• Main Authors: Cui, Liang, Balamkundu, Seetharamsing, Liu, Chuan-Fa, Ye, Hong, Hourihan, Jacob, Rausch, Astrid, Hauß, Christopher, Nilsson, Emelie, Hoetzinger, Matthias, Holmfeldt, Karin, Zhang, Weijia, Martinez-Alvarez, Laura, Peng, Xu, Tremblay, Denise, Moinau, Sylvain, Solonenko, Natalie, Sullivan, Matthew B., Lee, Yan-Jiun, Mulholland, Andrew, Weigele, Peter R., de Crécy-Lagard, Valérie, Dedon, Peter C., Hutinet, Geoffrey
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Amino acid sequence; Archaeal virus
• Online Access: https://hdl.handle.net/10356/174025
• Institution: Nanyang Technological University

Bacteriophages and bacteria are engaged in a constant arms race, continually evolving new molecular tools to survive one another. To protect their genomic DNA from restriction enzymes, the most common bacterial defence systems, double-stranded DNA phages have evolved complex modifications that affec...