Metal-organic framework-based nanovaccine for relieving immunosuppressive tumors via hindering efferocytosis of macrophages and promoting pyroptosis and cuproptosis of cancer cells

• Main Authors: Liu, Yang, Niu, Rui, Zhang, Xiaodong, Zhang, Bin, Chen, Xiaokai, Guo, Jingjing, Song, Shuyan, Wang, Yinghui, Zhang, Hongjie, Zhao, Yanli
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Cuproptosis; Immunotherapy
• Online Access: https://hdl.handle.net/10356/179393
• Institution: Nanyang Technological University

Current cancer vaccines face challenges due to an immunosuppressive tumor microenvironment and their limited ability to produce an effective immune response. To address the above limitations, we develop a 3-(2-spiroadamantyl)-4-methoxy-4-(3-phosphoryloxy)-phenyl-1,2-dioxetane (alkaline phosphatase s...