Synthetic route to quinolines via microwave irradiation assisted triflic acid-catalyzed friedländer annulation.

• 主要作者: Hoeng, Murni.
• 其他作者: Philip Wai Hong Chan
• 格式: Final Year Project
• 語言: English
• 出版: 2010
• 主題: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
• 在線閱讀: http://hdl.handle.net/10356/39834
• 機構: Nanyang Technological University

An efficient triflic acid-catalyzed Friedländer annulation of 2-aminobenzophenone and ketone to afford quinolines under microwave irradiation is reported herein. The methodology gives a variety of quinolines with moderate to high yields (30-90%), achieved with 5 mol% of the Brønsted acid.