Co-delivery of TGF-β3 and COL I-targeting shRNA with adenoviral and lentiviral vectors for COL I-surpressed in vitro chondrogenesis

• Main Author: M. K. Mohamed Idris
• Other Authors: Wang Dongan
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Virology; DRNTU::Science::Medicine::Tissue engineering
• Online Access: http://hdl.handle.net/10356/45690
• Institution: Nanyang Technological University

Cartilage degeneration poses a challenge to clinicians in spite of the various therapies that have been developed for its treatment. Cell-based therapy is promising due to its ability to restore the structure and function of the native cartilage as much as possible. Stromal-derived mesenchymal stem...