Structural study of ribosome : 1) structural basis of EF-G in translocation. 2) molecular mechanism of ribosome-dependent toxin YoeB in mRNA cleavage

• Main Author: Chen, Yun
• Other Authors: Gao Yonggui
• Format: Theses and Dissertations
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Biophysics
• Online Access: https://hdl.handle.net/10356/65648
• Institution: Nanyang Technological University

During bacterial protein synthesis, elongation factor G (EF-G) facilitates the forward movement of the tRNA–mRNA by one codon, which is coupled to the ratchet-like movement of the ribosome and triggered by EF-G–mediated GTP hydrolysis. This process, known as translocation, is the most conserved part...