Anti-endotoxic and antibacterial effects of a dermal substitute coated with host defense peptides

• Main Authors: Kasetty, Gopinath, Kalle, Martina, Mörgelin, Matthias, Brune, Jan C., Schmidtchen, Artur
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/79248; http://hdl.handle.net/10220/38647
• Institution: Nanyang Technological University

Biomaterials used during surgery and wound treatment are of increasing importance in modern medical care. In the present study we set out to evaluate the addition of thrombin-derived host defense peptides to human acellular dermis (hAD, i.e. epiflex®). Antimicrobial activity of the functionalized hA...