Scaffold mediated gene knockdown for neuronal differentiation of human neural progenitor cells

• Main Authors: Chooi, Wai Hon, Ong, William, Murray, Aoife, Lin, Junquan, Nizetic, Dean, Chew, Sing Yian
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Engineering::Bioengineering; DRNTU::Science::Medicine::Biomedical engineering
• Online Access: https://hdl.handle.net/10356/80401; http://hdl.handle.net/10220/46516
• Institution: Nanyang Technological University

The use of human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) is an attractive therapeutic option for damaged nerve tissues. To direct neuronal differentiation of stem cells, we have previously developed an electrospun polycaprolactone nanofiber scaffold that was functi...