The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface

• Main Authors: Rybtke, Morten, Berthelsen, Jens, Yang, Liang, Høiby, Niels, Givskov, Michael, Tolker-Nielsen, Tim
• Other Authors: Singapore Centre for Environmental Life Sciences Engineering
• Format: Article
• Language: English
• Published: 2016
• Subjects: Biofilm; C-di-GMP; Protease; Pseudomonas; Adhesin
• Online Access: https://hdl.handle.net/10356/81553; http://hdl.handle.net/10220/39586
• Institution: Nanyang Technological University

Pseudomonas aeruginosa is a clinically relevant species involved in biofilm-based chronic infections. We provide evidence that the P. aeruginosa LapG protein functions as a periplasmic protease that can cleave the protein adhesin CdrA off the cell surface, and thereby plays a role in biofilm formati...