Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations
Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types of cancers. Inhibition of Mnk prevents eIF4E phosphorylation, making them potent...
Saved in:
Main Authors: | Kannan, Srinivasaraghavan, Poulsen, Anders, Yang, Hai Yan, Ho, Melvyn, Ang, Shi Hua, Eldwin, Tan Sum Wai, Jeyaraj, Duraiswamy Athisayamani, Chennamaneni, Lohitha Rao, Liu, Boping, Hill, Jeffrey, Verma, Chandra Shekhar, Nacro, Kassoum |
---|---|
Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2016
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/81961 http://hdl.handle.net/10220/41065 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
Similar Items
-
Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations
by: Kannan, Srinivasaraghavan, et al.
Published: (2016) -
Small molecules targeting the inactive form of the Mnk1/2 kinases
by: Kannan, Srinivasaraghavan, et al.
Published: (2021) -
Caspase-3 is necessary and sufficient for cleavage of protein synthesis eukaryotic initiation factor 4G during apoptosis
by: Bushell, M., et al.
Published: (2014) -
Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex
by: Frosi, Yuri, et al.
Published: (2023) -
Effect of Ser392 Phosphorylation on the Structure and Dynamics of the Polybasic Domain of ADP Ribosylation Factor Nucleotide Site Opener Protein: A Molecular Simulation Study
by: Srinivasaraghavan, Kannan, et al.
Published: (2016)