Klf2 Is an Essential Factor that Sustains Ground State Pluripotency

Klf2 Is an Essential Factor that Sustains Ground State Pluripotency

The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum. However, a pluripotent “ground state,” bearing resemblance to preimplantation mouse epiblasts, can be established through dual inhibition (2i) of both prodifferentiation Mek/Erk and Gsk3/Tcf3 pathways. While Gsk3 inhibitio...

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Bibliographic Details
Main Authors: Yeo, Jia-Chi, Jiang, Jianming, Tan, Zi-Ying, Yim, Guo-Rong, Ng, Jia-Hui, Göke, Jonathan, Kraus, Petra, Liang, Hongqing, Gonzales, Kevin Andrew Uy, Chong, Han-Chung, Tan, Cheng-Peow, Lim, Yee-Siang, Tan, Nguan-Soon, Lufkin, Thomas, Ng, Huck-Hui
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2016
Online Access:https://hdl.handle.net/10356/82151
http://hdl.handle.net/10220/41099
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Institution: Nanyang Technological University
Language: English

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