Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection

• Main Authors: Hasenoehrl, Erik J., Koh, Vanessa H., Ang, Michelle L. T., Sajorda, Dannah R., Hards, Kiel, Grüber, Gerhard, Alonso, Sylvie, Cook, Gregory M., Berney, Michael, Pethe, Kevin, Kalia, Nitin Pal, Ab Rahman, Nurlilah Binte
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Bioenergetics; Oxidative Phosphorylation
• Online Access: https://hdl.handle.net/10356/84353; http://hdl.handle.net/10220/43577
• Institution: Nanyang Technological University

The recent discovery of small molecules targeting the cytochrome bc 1 : aa 3 in Mycobacterium tuberculosis triggered interest in the terminal respiratory oxidases for antituberculosis drug development. The mycobacterial cytochrome bc 1 : aa 3 consists of a menaquinone:cytochrome c reductase ( bc 1 )...