The rapid in vivo evolution of Pseudomonas aeruginosa in ventilator-associated pneumonia patients leads to attenuated virulence

• Main Authors: Wang, Ke, Chen, Yi-qiang, Salido, May M., Kohli, Gurjeet S., Kong, Jin-liang, Liang, Hong-jie, Yao, Zi-ting, Xie, Yan-tong, Wu, Hua-yu, Cai, Shuang-qi, Drautz-Moses, Daniela I., Darling, Aaron E., Schuster, Stephan C., Yang, Liang, Ding, Yichen
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Pseudomonas Aeruginosa; Ventilator-associated Pneumonia; DRNTU::Engineering::Environmental engineering
• Online Access: https://hdl.handle.net/10356/85357; http://hdl.handle.net/10220/48202
• Institution: Nanyang Technological University

Pseudomonas aeruginosa is an opportunistic pathogen that causes severe airway infections in humans. These infections are usually difficult to treat and associated with high mortality rates. While colonizing the human airways, P. aeruginosa could accumulate genetic mutations that often lead to its be...