A role of Agrin in maintaining the stability of vascular endothelial growth factor receptor-2 during tumor angiogenesis

• Main Authors: Njah, Kizito, Chakraborty, Sayan, Qiu, Beiying, Arumugam, Surender, Raju, Anandhkumar, Pobbati, Ajaybabu V., Lakshmanan, Manikandan, Tergaonkar, Vinay, Thibault, Guillaume, Wang, Xiaomeng, Hong, Wanjin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Agrin; Tumor Angiogenesis; Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/87097; http://hdl.handle.net/10220/49876
• Institution: Nanyang Technological University

Endothelial cell (EC) recruitment is central to the vascularization of tumors. Although several proteoglycans have been implicated in cancer and angiogenesis, their roles in EC recruitment and vascularization during tumorigenesis remain poorly understood. Here, we reveal that Agrin, which is secrete...