Development of novel agonists for the orphan nuclear receptor, Nurr1 : a therapeutic strategy for Parkinson’s disease

Development of novel agonists for the orphan nuclear receptor, Nurr1 : a therapeutic strategy for Parkinson’s disease

Parkinson’s Disease (PD) is the second most prevalent neurodegenerative disease among the elderly. It is characterized pathologically by the demise of dopaminergic (DA) neurons in the substantia nigra region of the midbrain resulting in the loss of motor function. The orphan nuclear receptor, Nurr1,...

Saved in:

書目詳細資料
主要作者:	Toh, Hui Ting
其他作者:	Liu Xuewei
格式:	Thesis-Doctor of Philosophy
語言:	English
出版:	Nanyang Technological University 2019
主題:	DRNTU::Science::Biological sciences
在線閱讀:	https://hdl.handle.net/10356/89266 http://hdl.handle.net/10220/48045
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

相似書籍

Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease
由: Kim, Chun-Hyung, et al.
出版: (2015)

Structural and molecular characterization of ligands activating the orphan nuclear receptor Nurr1 (NR4A2)
由: Ng, Xin Yi
出版: (2019)

Nurr1 mutational screen in Parkinson's disease
由: Tan E.-K., et al.
出版: (2018)

Genetic analysis of Nurr1 haplotypes in Parkinson's disease
由: Tan E.-K., et al.
出版: (2018)

Prostaglandin A2 interacts with Nurr1 and ameliorates behavioral deficits in Parkinson's disease fly model
由: Rajan, Sreekanth, et al.
出版: (2022)

Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases
由: Park, Tae-Yoon, et al.
出版: (2020)

Orphan G Protein-Coupled Receptors and Novel Neuropeptides
由: Olivier Civelli, et al.
出版: (2017)

Choosing dopamine agonists in Parkinson's disease
由: Tan E.-K., et al.
出版: (2018)

Characterization of novel neuroprotective ligands modulating molecular behavior of alpha synuclein in Parkinson's disease
由: Toh, Hui Ting
出版: (2014)

Dopamine agonists and their role in Parkinson's disease treatment
由: Tan E.-K.
出版: (2018)

The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation
由: Mary P. Lee, et al.
出版: (2018)

Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb
由: Feng, B., et al.
出版: (2014)

Targeting Nuclear Receptors in Lung Cancer-Novel Therapeutic Prospects
由: Gangwar, Shailendra Kumar, et al.
出版: (2023)

Peripheral edema and dopamine agonists in Parkinson disease [5]
由: Tan E.-K.
出版: (2018)

Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis
由: Chen, H.-Z., et al.
出版: (2014)

EVALUATING THE THERAPEUTIC POTENTIAL OF ORPHAN G-PROTEIN COUPLED RECEPTORS: GPR19 AND GPR17
由: ANGAD RAO
出版: (2017)

PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
由: Rajan, Sreekanth, et al.
出版: (2022)

Nuclear microscopy in Parkinson's disease
由: Watt, F., et al.
出版: (2014)

Mitochondrial dysfunction and Parkinson’s disease — near-infrared photobiomodulation as a potential therapeutic strategy
由: Foo, Aaron Song Chuan, et al.
出版: (2021)

The NR4A orphan nuclear receptors are target genes of the novel drug C1 in cancer cells and potential mediators of drug induced apoptosis
由: KALA RAMASESHAN
出版: (2010)

Parkinson's disease: Developing therapeutic strategies from understanding pathophysiology
由: Leong, L.K.
出版: (2014)

Melatonin and its agonist ramelteon in Alzheimer's disease: Possible therapeutic value
由: Cardinali D.P., et al.
出版: (2018)

REPOSITIONING DRUG OF GLP-1 AGONIST IN PARKINSON DISEASE BASED ON MACHINE LEARNING AND MOLECULAR DOCKING
由: Hasnia Putri, Haliza

EXPLORATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AGONIST IN ALZHEIMER'S DISEASETHERAPY - A THERAPEUTIC ENIGMA
由: CHANG KAI LUN
出版: (2015)

Identification of novel therapeutic candidates to treat autoimmune diseases
由: Lim, Eugene Hui Kiat
出版: (2018)

The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification
由: Lee, M.B, et al.
出版: (2020)

Characterisation of RIG-I-like receptor agonists for dengue virus therapy or vaccination
由: Ho, Victor Chin Yong
出版: (2019)

Evaluation of novel Parkinson's disease candidate genes in the Chinese population
由: Chew, Elaine Guo Yan, et al.
出版: (2020)

LRRK2 as a therapeutic target in Parkinson's disease
由: Tan, E.K., et al.
出版: (2014)

Rotigotine transdermal system as add-on to oral dopamine agonist in advanced Parkinson's disease: An open-label study
由: Kim J.-M., et al.
出版: (2018)

Mitochondrial Dysfunction and Parkinson’s Disease—Near-Infrared Photobiomodulation as a Potential Therapeutic Strategy
由: Foo, A.S.C., et al.
出版: (2021)

Targeting the renin-angiotensin system as novel therapeutic strategy for pulmonary diseases
由: Tan, Wan Shun Daniel, et al.
出版: (2023)

The orphan nuclear receptor NR0B2 could be a novel susceptibility locus associated with microsatellite-stable, APC mutation-negative early-onset colorectal carcinomas with metabolic manifestation.
由: Lam, Kuen Kuen, et al.
出版: (2020)

Nuclear microscope analysis in Alzheimer's and Parkinson's disease: A review.
由: Watt, F.
出版: (2014)

Glucagon-Like Peptide-1 Receptor Agonists for Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: A Meta-Analysis
由: Wong, Chloe, et al.
出版: (2021)

The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation
由: Tan M.H.E., et al.
出版: (2018)

Pharmacophore-guided Virtual Screening to Identify New β3-adrenergic Receptor Agonists
由: Ujiantari, Navista Sri Octa, et al.
出版: (2022)

Muscarinic M1 Receptor Coupling to G-protein is Intact in Parkinson's Disease Dementia
由: Lee, Jasinda H, et al.
出版: (2021)

Functional characterization of Nurr1 and Pin1 in neuronal progenitor cell differentiation
由: DONG BEIBEI
出版: (2010)

Therapeutic effect of Hydrogen sulfide in a Parkinson's disease model
由: XIE LI
出版: (2012)