Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation
Neural-Wiskott Aldrich Syndrome Protein (N-WASP) is expressed ubiquitously and regulates actin cytoskeleton remodeling. In order to characterize the role of N-WASP in epidermal homeostasis and cutaneous biology, we generated conditional N-WASP knockout mouse using CK14-cre (cytokeratin 14) to ablate...
Saved in:
Main Authors: | Kalailingam, Pazhanichamy, Tan, Hui Bing, Jain, Neeraj, Sng, Ming Keat, Chan, Jeremy Soon Kiat, Tan, Nguan Soon, Thanabalu, Thirumaran |
---|---|
Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Article |
Language: | English |
Published: |
2018
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/89475 http://hdl.handle.net/10220/44984 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
Similar Items
-
Conditional knockout of N-WASP in mouse fibroblast caused keratinocyte hyper proliferation and enhanced wound closure
by: Kalailingam, Pazhanichamy, et al.
Published: (2017) -
N-WASP attenuates cell proliferation and migration through ERK2-dependent enhanced expression of TXNIP
by: Chung, Yat Joong, et al.
Published: (2022) -
Olive-derived antioxidant dietary fiber modulates gut microbiota composition and attenuates atopic dermatitis like inflammation in mice
by: Lee, YingHui, et al.
Published: (2023) -
Conditional N-WASP knockout in mouse brain implicates actin cytoskeleton regulation in hydrocephalus pathology
by: Jain, Neeraj, et al.
Published: (2015) -
Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α
by: Jain, Neeraj, et al.
Published: (2015)