Carbon metabolism modulates the efficacy of drugs targeting the cytochrome bc1:aa3 in Mycobacterium tuberculosis

• المؤلفون الرئيسيون: Moraski, Garrett C., Miller, Marvin J., Pethe, Kevin, Kalia, Nitin Pal, Lee, Bei Shi, Nurlilah Ab Rahman
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Tuberculosis; Antimicrobials; Science::Chemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/89857; http://hdl.handle.net/10220/49328

The influence of carbon metabolism on oxidative phosphorylation is poorly understood in mycobacteria. M. tuberculosis expresses two respiratory terminal oxidases, the cytochrome bc1:aa3 and the cytochrome bd oxidase, which are jointly required for oxidative phosphorylation and mycobacterial viabilit...