Enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes

An enantioselective and direct oxidative coupling of aldehydes to tertiary amines to give β-amino alcohols is described. Catalyzed by copper(II), the reaction proceeds to give a racemic mixture of products; however, by using a combination of copper(II) and a chiral amine catalyst, the reaction gives...

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Bibliographic Details
Main Authors: Zhang, Junmin, Tiwari, Bhoopendra, Xing, Chong, Chen, Xingkuan, Chi, Robin Yonggui
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2012
Subjects:
Online Access:https://hdl.handle.net/10356/94637
http://hdl.handle.net/10220/8116
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Institution: Nanyang Technological University
Language: English
Description
Summary:An enantioselective and direct oxidative coupling of aldehydes to tertiary amines to give β-amino alcohols is described. Catalyzed by copper(II), the reaction proceeds to give a racemic mixture of products; however, by using a combination of copper(II) and a chiral amine catalyst, the reaction gives the desired products with high enantioselectivity.