Enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes

Enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes

An enantioselective and direct oxidative coupling of aldehydes to tertiary amines to give β-amino alcohols is described. Catalyzed by copper(II), the reaction proceeds to give a racemic mixture of products; however, by using a combination of copper(II) and a chiral amine catalyst, the reaction gives...

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Main Authors: Zhang, Junmin, Tiwari, Bhoopendra, Xing, Chong, Chen, Xingkuan, Chi, Robin Yonggui
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2012
Subjects:
DRNTU::Science::Mathematics::Applied mathematics
Online Access:https://hdl.handle.net/10356/94637
http://hdl.handle.net/10220/8116
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-946372020-03-07T12:31:30Z Enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes Zhang, Junmin Tiwari, Bhoopendra Xing, Chong Chen, Xingkuan Chi, Robin Yonggui School of Physical and Mathematical Sciences DRNTU::Science::Mathematics::Applied mathematics An enantioselective and direct oxidative coupling of aldehydes to tertiary amines to give β-amino alcohols is described. Catalyzed by copper(II), the reaction proceeds to give a racemic mixture of products; however, by using a combination of copper(II) and a chiral amine catalyst, the reaction gives the desired products with high enantioselectivity. 2012-05-22T08:43:27Z 2019-12-06T18:59:33Z 2012-05-22T08:43:27Z 2019-12-06T18:59:33Z 2012 2012 Journal Article Zhang, J., Tiwari, B., Xing, C., Chen, X. & Chi, R. Y. (2012). Enantioselective Oxidative Cross-Dehydrogenative Coupling of Tertiary Amines to Aldehydes. Angewandte Chemie International Edition, 51(15), 3649-3652. https://hdl.handle.net/10356/94637 http://hdl.handle.net/10220/8116 10.1002/anie.201109054 165019 en Angewandte chemie international edition © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Science::Mathematics::Applied mathematics
spellingShingle DRNTU::Science::Mathematics::Applied mathematics
Zhang, Junmin
Tiwari, Bhoopendra
Xing, Chong
Chen, Xingkuan
Chi, Robin Yonggui
Enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes
description An enantioselective and direct oxidative coupling of aldehydes to tertiary amines to give β-amino alcohols is described. Catalyzed by copper(II), the reaction proceeds to give a racemic mixture of products; however, by using a combination of copper(II) and a chiral amine catalyst, the reaction gives the desired products with high enantioselectivity.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Zhang, Junmin
Tiwari, Bhoopendra
Xing, Chong
Chen, Xingkuan
Chi, Robin Yonggui
format Article
author Zhang, Junmin
Tiwari, Bhoopendra
Xing, Chong
Chen, Xingkuan
Chi, Robin Yonggui
author_sort Zhang, Junmin
title Enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes
title_short Enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes
title_full Enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes
title_fullStr Enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes
title_full_unstemmed Enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes
title_sort enantioselective oxidative cross-dehydrogenative coupling of tertiary amines to aldehydes
publishDate 2012
url https://hdl.handle.net/10356/94637
http://hdl.handle.net/10220/8116
_version_ 1681042340231249920

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