Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide

• Main Authors: Alag, Reema, Bharatham, Nagakumar, Dong, Aiping, Hills, Tanya, Harikishore, Amaravadhi, Widjaja, Anissa Anindya, Shochat, Susana Geifman, Hui, Raymond, Yoon, Ho Sup
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Chemistry::Analytical chemistry::Proteins
• Online Access: https://hdl.handle.net/10356/95073; http://hdl.handle.net/10220/8710
• Institution: Nanyang Technological University

Plasmodium falciparum FK506-binding protein 35 (PfFKBP35) that binds to FK506 contains a conserved tetratricopeptide repeat (TPR) domain. Several known TPR domains such as Hop, PPP5, CHIP, and FKBP52 are structurally conserved and are able to interact with molecular chaperones such as Hsp70/Hsp90. H...